V. Sharma and A. Swaminathan contributed equally to this work.
Patterns & Phenotypes
Drosophila SIN3 is required at multiple stages of development
Article first published online: 24 SEP 2008
Copyright © 2008 Wiley-Liss, Inc.
Special Issue: Special Focus on the Extracellular Matrix, in Memory of Dr. Elizabeth D. Hay
Volume 237, Issue 10, pages 3040–3050, October 2008
How to Cite
Sharma, V., Swaminathan, A., Bao, R. and Pile, L. A. (2008), Drosophila SIN3 is required at multiple stages of development. Dev. Dyn., 237: 3040–3050. doi: 10.1002/dvdy.21706
- Issue published online: 24 SEP 2008
- Article first published online: 24 SEP 2008
- Manuscript Accepted: 17 JUL 2008
- American Cancer Society. Grant Number: Research Scholar Grant
- Wayne State University
SIN3 is a component of a histone deacetylase complex known to be important for transcription repression. While multiple isoforms of SIN3 have been reported, little is known about their relative expression or role in development. Using a combination of techniques, we have determined that SIN3 is expressed throughout the Drosophila life cycle. The pattern of expression for each individual isoform, however, is distinct. Knock down of all SIN3 expression reveals a requirement for this protein in embryonic and larval periods. Taken together, the data suggest that SIN3 is required for multiple developmental events during the Drosophila life cycle. Developmental Dynamics 237:3040–3050, 2008. © 2008 Wiley-Liss, Inc.