Patterns & Phenotypes
Differential requirements for Fgf3 and Fgf8 during mouse forebrain development
Article first published online: 21 OCT 2008
Copyright © 2008 Wiley-Liss, Inc.
Volume 237, Issue 11, pages 3417–3423, November 2008
How to Cite
Theil, T., Dominguez-Frutos, E. and Schimmang, T. (2008), Differential requirements for Fgf3 and Fgf8 during mouse forebrain development. Dev. Dyn., 237: 3417–3423. doi: 10.1002/dvdy.21765
- Issue published online: 21 OCT 2008
- Article first published online: 21 OCT 2008
- Manuscript Accepted: 1 SEP 2008
- Spanish Ministry of Education and Science. Grant Number: BFU2007-60130
- Ciberned, TerCel
- Junta de Castilla y León
- fibroblast growth factor;
- conditional knockout
Multiple Fgfs are expressed during formation and patterning of the telencephalon in vertebrates. Fgf8 has been shown to control the size of the telencephalon and the development of signaling centers in zebrafish and mouse. Next to Fgf8, Fgf3 also influences telencephalic gene expression in the zebrafish. Moreover, Fgf3 and Fgf8 have been shown to have combinatorial functions during forebrain development in this species. Here, we have examined telencephalic development in Fgf3 null mouse mutants and embryos that lack both Fgf3 and Fgf8 in their forebrain. In contrast to zebrafish, Fgf3 mutants show normal forebrain development and expression of telencephalic marker genes. Although double mutants for Fgf3 and Fgf8 show a further reduction of forebrain size no additional changes of telencephalic gene expression are observed compared with Fgf8 mutants. Therefore unlike in zebrafish, Fgf3 is not required for mouse forebrain development whereas Fgf8 has a central role during this process. Developmental Dynamics 237:3417–3423, 2008. © 2008 Wiley-Liss, Inc.