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Stretching the limits: Stem cells in regeneration science

  1. David L. Stocum1,*,
  2. Günther K.H. Zupanc2

Article first published online: 4 NOV 2008

DOI: 10.1002/dvdy.21774

Issue

Developmental Dynamics

Developmental Dynamics

Special Issue: Special Focus on Left-Right Asymmetry

Volume 237, Issue 12, pages 3648–3671, December 2008

Additional Information

How to Cite

Stocum, D. L. and Zupanc, G. K. (2008), Stretching the limits: Stem cells in regeneration science. Developmental Dynamics, 237: 3648–3671. doi: 10.1002/dvdy.21774

Author Information

  1. 1

    Department of Biology and Indiana University Center for Regenerative Biology and Medicine, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana

  2. 2

    School of Engineering and Science, Jacobs University Bremen, Bremen, Germany

*723 W. Michigan Street, Indianapolis, IN 46202

Publication History

  1. Issue published online: 20 NOV 2008
  2. Article first published online: 4 NOV 2008
  3. Manuscript Accepted: 10 SEP 2008

Funded by

  • U.S. Army Research Laboratory and the U.S. Army Research Office. Grant Number: W911NF07-10176
  • W.M. Keck Foundation
  • International Center for Transdisciplinary Studies of Jacobs University Bremen

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Keywords:

  • regenerative medicine;
  • stem cells;
  • adult stem cells;
  • embryonic stem cells;
  • induced pluripotent stem cells;
  • compensatory hyperplasia;
  • dedifferentaition;
  • chemical induction;
  • fish;
  • amphibians

Abstract

The focus of regenerative medicine is rebuilding damaged tissues by cell transplantation or implantation of bioartificial tissues. In either case, therapies focus on adult stem cells (ASCs) and embryonic stem cells (ESCs) as cell sources. Here we review four topics based on these two cell sources. The first compares the current performance of ASCs and ESCs as cell transplant therapies and the drawbacks of each. The second explores somatic cell nuclear transfer (SCNT) as a method to derive ESCs that will not be immunorejected. The third topic explores how SCNT and ESC research has led to the ability to derive pluripotent ESCs by the dedifferentiation of adult somatic cells. Lastly, we discuss how research on activation of intrinsic adult stem cells and on somatic cell dedifferentiation can evolve regenerative medicine from a platform consisting of cell transplantation to one that includes the chemical induction of regeneration from the body's own cells at the site of injury. Developmental Dynamics 237:3648–3671, 2008. © 2008 Wiley-Liss, Inc.

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