Patterns & Phenotypes
Samba, a Xenopus hnRNP expressed in neural and neural crest tissues
Article first published online: 18 DEC 2008
Copyright © 2008 Wiley-Liss, Inc.
Volume 238, Issue 1, pages 204–209, January 2009
How to Cite
Yan, C. Y. I., Skourides, P., Chang, C. and Brivanlou, A. (2009), Samba, a Xenopus hnRNP expressed in neural and neural crest tissues. Dev. Dyn., 238: 204–209. doi: 10.1002/dvdy.21826
- Issue published online: 18 DEC 2008
- Article first published online: 18 DEC 2008
- Manuscript Accepted: 26 OCT 2008
- neural crest migration;
- RNA binding protein (RBP)
RNA binding proteins regulate gene expression at the posttranscriptional level and play important roles in embryonic development. Here, we report the cloning and expression of Samba, a Xenopus hnRNP that is maternally expressed and persists at least until tail bud stages. During gastrula stages, Samba is enriched in the dorsal regions. Subsequently, its expression is elevated only in neural and neural crest tissues. In the latter, Samba expression overlaps with that of Slug in migratory neural crest cells. Thereafter, Samba is maintained in the neural crest derivatives, as well as other neural tissues, including the anterior and posterior neural tube and the eyes. Overexpression of Samba in the animal pole leads to defects in neural crest migration and cranial cartilage development. Thus, Samba encodes a Xenopus hnRNP that is expressed early in neural and neural crest derivatives and may regulate crest cells migratory behavior. Developmental Dynamics 238:204–209, 2009. © 2008 Wiley-Liss, Inc.