Special Issue Patterns & Phenotypes
The Flk1-myr::mCherry mouse as a useful reporter to characterize multiple aspects of ocular blood vessel development and disease
Article first published online: 27 FEB 2009
Copyright © 2009 Wiley-Liss, Inc.
Special Issue: Special Focus on Visual Systems
Volume 238, Issue 9, pages 2318–2326, September 2009
How to Cite
Poché, R. A., Larina, I. V., Scott, M. L., Saik, J. E., West, J. L. and Dickinson, M. E. (2009), The Flk1-myr::mCherry mouse as a useful reporter to characterize multiple aspects of ocular blood vessel development and disease. Dev. Dyn., 238: 2318–2326. doi: 10.1002/dvdy.21886
- Issue published online: 13 AUG 2009
- Article first published online: 27 FEB 2009
- Manuscript Accepted: 7 JAN 2009
- The National Institute of Health. Grant Numbers: T32EY07102, T32HD055200, R01HL077187, R01EB005173-01/05, P20EB007076
- American Heart Association. Grant Number: 0625187Y
- endothelial cells;
- blood vessels;
The highly vascularized mouse eye is an excellent model system in which to elucidate the molecular genetic basis of blood vessel development and disease. However, the analysis of ocular vessel defects has traditionally been derived from fixed tissue, which fails to account for dynamic events such as blood flow and cell migration. To overcome the limitations of static analysis, tremendous advances in imaging technology and fluorescent protein reporter mouse lines now enable the direct visualization of developing cells in vivo. Here, we demonstrate that the Flk1-myr::mCherry transgenic mouse is an extremely useful live reporter with broad applicability to retinal, hyaloid, and choroid vascular research. Developmental Dynamics 238:2318–2326, 2009. © 2009 Wiley-Liss, Inc.