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Xenopus pancreas development

  1. Esther J. Pearl1,2,3,
  2. Cassandra K. Bilogan1,3,4,
  3. Sandeep Mukhi5,
  4. Donald D. Brown5,
  5. Marko E. Horb1,2,3,4,*

Article first published online: 30 MAR 2009

DOI: 10.1002/dvdy.21935

Issue

Developmental Dynamics

Developmental Dynamics

Special Issue: Special Focus on Xenopus

Volume 238, Issue 6, pages 1271–1286, June 2009

Additional Information

How to Cite

Pearl, E. J., Bilogan, C. K., Mukhi, S., Brown, D. D. and Horb, M. E. (2009), Xenopus pancreas development. Dev. Dyn., 238: 1271–1286. doi: 10.1002/dvdy.21935

Author Information

  1. 1

    Laboratory of Molecular Organogenesis, Institut de Recherches Cliniques de Montréal, Montréal, QC Canada

  2. 2

    Département de Médecine, Université de Montréal, Montréal, Canada

  3. 3

    Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Canada

  4. 4

    Division of Experimental Medicine and Department of Anatomy and Cell Biology, McGill University, Montréal, Canada

  5. 5

    Department of Embryology, Carnegie Institution, Baltimore, Maryland

*Laboratory of Molecular Organogenesis, Institut de Recherches Cliniques de Montréal, 110 Avenue des Pin Ouest, Montréal, H2W1R7, Québec, Canada

Publication History

  1. Issue published online: 12 MAY 2009
  2. Article first published online: 30 MAR 2009
  3. Manuscript Accepted: 21 FEB 2009

Funded by

  • National Institute of Diabetes and Digestive and Kidney Diseases, NIH. Grant Numbers: 5R01DK77197-02, 2 R01 GM022395-33
  • Juvenile Diabetes Research Foundation. Grant Number: 6-2007-910
  • G. Harold and Leila Y. Mathers Charitable Trust

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Keywords:

  • Xenopus;
  • pancreas;
  • RA;
  • Wnt;
  • TGFβ;
  • Pdx1;
  • Ptf1a;
  • metamorphosis;
  • thyroid hormone

Abstract

Understanding how the pancreas develops is vital to finding new treatments for a range of pancreatic diseases, including diabetes and pancreatic cancer. Xenopus is a relatively new model organism for the elucidation of pancreas development, and has already made contributions to the field. Recent studies have shown benefits of using Xenopus for understanding both early patterning and lineage specification aspects of pancreas organogenesis. This review focuses specifically on Xenopus pancreas development, and covers events from the end of gastrulation, when regional specification of the endoderm is occurring, right through metamorphosis, when the mature pancreas is fully formed. We have attempted to cover pancreas development in Xenopus comprehensively enough to assist newcomers to the field and also to enable those studying pancreas development in other model organisms to better place the results from Xenopus research into the context of the field in general and their studies specifically. Developmental Dynamics 238:1271–1286, 2009. © 2009 Wiley-Liss, Inc.

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