Mitotic patterns in the migrating lateral line cells of zebrafish embryos
Article first published online: 30 MAR 2009
Copyright © 2009 Wiley-Liss, Inc.
Volume 238, Issue 5, pages 1042–1051, May 2009
How to Cite
Laguerre, L., Ghysen, A. and Dambly-Chaudière, C. (2009), Mitotic patterns in the migrating lateral line cells of zebrafish embryos. Dev. Dyn., 238: 1042–1051. doi: 10.1002/dvdy.21938
- Issue published online: 21 APR 2009
- Article first published online: 30 MAR 2009
- Manuscript Accepted: 21 FEB 2009
- Association pour la Recherche sur le Cancer (ARC). Grant Number: 4876
- cell proliferation;
- cell migration;
- determinate lineage
The sense organs of the posterior lateral line system (neuromasts) are formed by a migrating primordium. In zebrafish, the primordium comprises approximately 100 cells at the onset of migration, and has deposited approximately 300 cells by the end of the process. Here, we report localized phases of mitotic activity and of mitotic quiescence within the migrating primordium. Quiescence in the leading region seems associated to the formation of a new prospective neuromast, whereas quiescence in the trailing region follows a wave of mitoses that synchronize trailing cells in G0/G1 phase, anticipating neuromast differentiation. Manipulating the size of the primordium does not lead to changes in the rate of cell proliferation. We also show that two mitoses often take place nearly synchronously in adjacent cells, suggestive of a determinate lineage. We conclude that proliferation in the migrating primordium follows a stereotyped pattern that closely anticipates the normal development of the system. Developmental Dynamics 238:1042–1051, 2009. © 2009 Wiley-Liss, Inc.