Patterns & Phenotypes
Transcriptome analysis of the zebrafish pineal gland
Article first published online: 4 JUN 2009
Copyright © 2009 Wiley-Liss, Inc.
Volume 238, Issue 7, pages 1813–1826, July 2009
How to Cite
Toyama, R., Chen, X., Jhawar, N., Aamar, E., Epstein, J., Reany, N., Alon, S., Gothilf, Y., Klein, D. C. and Dawid, I. B. (2009), Transcriptome analysis of the zebrafish pineal gland. Dev. Dyn., 238: 1813–1826. doi: 10.1002/dvdy.21988
- Issue published online: 10 JUN 2009
- Article first published online: 4 JUN 2009
- Manuscript Accepted: 11 APR 2009
- United States-Israel Binational Science Foundation (BSF), Jerusalem, Israel
- Intramural Research Program of the NICHD
- pineal gland;
- circadian rhythm;
The zebrafish pineal gland (epiphysis) is a site of melatonin production, contains photoreceptor cells, and functions as a circadian clock pace maker. Here, we have used microarray technology to study the zebrafish pineal transcriptome. Analysis of gene expression at three larval and two adult stages revealed a highly dynamic transcriptional profile, revealing many genes that are highly expressed in the zebrafish pineal gland. Statistical analysis of the data based on Gene Ontology annotation indicates that many transcription factors are highly expressed during larval stages, whereas genes dedicated to phototransduction are preferentially expressed in the adult. Furthermore, several genes were identified that exhibit day/night differences in expression. Among the multiple candidate genes suggested by these data, we note the identification of a tissue-specific form of the unc119 gene with a possible role in pineal development. Developmental Dynamics 238:1813–1826, 2009. © 2009 Wiley-Liss, Inc.