Regulation of organ size: Insights from the Drosophila Hippo signaling pathway

Authors

  • Madhuri Kango-Singh,

    Corresponding author
    1. Division of Basic Sciences, Mercer University School of Medicine, Macon Georgia
    • Division of Basic Sciences, Box 173, West 97, Mercer University School of Medicine, 1550 College Street, Macon, GA 31207
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  • Amit Singh

    Corresponding author
    1. Department of Biology, University of Dayton, Dayton Ohio
    2. Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, Ohio
    • Department of Biology, Center for Tissue Regeneration & Engineering at Dayton (TREND), University of Dayton, 300 College Park, Dayton, OH 45469
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Abstract

Organ size control is a fundamental and core process of development of all multicellular organisms. One important facet of organ size control is the regulation of cell proliferation and cell death. Here we address the question, What are the developmental mechanisms that control intrinsic organ size? In several multicellular animals including humans and flies, organs develop according to an instructive model where proliferation is regulated by extracellular signals. However, the signals that regulate proliferation (and organ size) remain poorly understood. Recent data from flies have shed some light on the molecular mechanisms that regulate growth and size of organs. In this review, we will briefly discuss classic studies that revealed the mysteries of growth regulation. We will then focus on the recent findings from the Drosophila Hippo signaling pathway and its role in the regulation of organ size. Finally, we will discuss the mammalian Hippo pathway, and its implications in regulation of growth/proliferation during development and disease. Developmental Dynamics 238:1627–1637, 2009. © 2009 Wiley-Liss, Inc.

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