Special Issue Research Article
Role of Wnt signaling in the biology of the periodontium
Article first published online: 15 JUN 2009
Copyright © 2009 Wiley-Liss, Inc.
Special Issue: Special Issue on WNT Signaling in Development and Disease
Volume 239, Issue 1, pages 140–147, January 2010
How to Cite
Rooker, S. M., Liu, B. and Helms, J. A. (2010), Role of Wnt signaling in the biology of the periodontium. Dev. Dyn., 239: 140–147. doi: 10.1002/dvdy.22003
- Issue published online: 15 DEC 2009
- Article first published online: 15 JUN 2009
- Manuscript Accepted: 5 MAY 2009
- NIH. Grant Number: 2R01EB000504-05
- CIRM. Grant Number: TR1-01249
- periodontal ligament;
Continuously erupting teeth have associated with them a continuously regenerating periodontal ligament, but the factors that control this amazing regenerative potential are unknown. We used genetic strategies to show that the periodontal ligament arises from the cranial neural crest. Despite their histological similarity, the periodontal ligament of continuously erupting incisor teeth differs dramatically from the periodontal ligament of molar teeth. The most notable difference was in the distribution of Wnt responsive cells in the incisor periodontal ligament, which coincided with regions of periodontal ligament cell proliferation. We discuss these findings in the context of dental tissue regeneration. Developmental Dynamics 239:140–147, 2010. © 2009 Wiley-Liss, Inc.