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Keywords:

  • protein kinase;
  • Wnt;
  • β-catenin;
  • GSK3;
  • CKI

Abstract

The Wnt/β-catenin signaling pathway plays essential roles during development and adult tissue homeostasis. Inappropriate activation of the pathway can result in a variety of malignancies. Protein kinases have emerged as key regulators at multiple steps of the Wnt pathway. In this review, we present a synthesis covering the latest information on how Wnt signaling is regulated by diverse protein kinases. Developmental Dynamics 239:34–44, 2010. © 2009 Wiley-Liss, Inc.