SEARCH

SEARCH BY CITATION

REFERENCES

  • Aguilera O, Fraga MF, Ballestar E, Paz MF, Herranz M, Espada J, Garcia JM, Munoz A, Esteller M, Gonzalez-Sancho JM. 2006. Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Oncogene 25: 41164121.
  • Assou S, Le Carrour T, Tondeur S, Strom S, Gabelle A, Marty S, Nadal L, Pantesco V, Reme T, Hugnot JP, Gasca S, Hovatta O, Hamamah S, Klein B, De Vos J. 2007. A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas. Stem Cells 25: 961973.
  • Brabletz T, Jung A, Dag S, Hlubek F, Kirchner T. 1999. beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am J Pathol 155: 10331038.
  • Brabletz T, Jung A, Reu S, Porzner M, Hlubek F, Kunz-Schughart LA, Knuechel R, Kirchner T. 2001. Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc Natl Acad Sci USA 98: 10356-10361.
  • Brabletz T, Hlubek F, Spaderna S, Schmalhofer O, Hiendlmeyer E, Jung A, Kirchner T. 2005a. Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin. Cells Tissues Organs 179: 5665.
  • Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T. 2005b. Opinion: migrating cancer stem cells: an integrated concept of malignant tumour progression. Nat Rev Cancer 5: 744749.
  • Caldwell GM, Jones C, Gensberg K, Jan S, Hardy RG, Byrd P, Chughtai S, Wallis Y, Matthews GM, Morton DG. 2004. The Wnt antagonist sFRP1 in colorectal tumorigenesis. Cancer Res 64: 883888.
  • Clevers H. 2006. Wnt/beta-catenin signaling in development and disease. Cell 127: 469480.
  • Dormeyer W, van Hoof D, Braam SR, Heck AJ, Mummery CL, Krijgsveld J. 2008. Plasma membrane proteomics of human embryonic stem cells and human embryonal carcinoma cells. J Proteome Res 7: 29362951.
  • Gradl D, Kuhl M, Wedlich D. 1999. The Wnt/Wg signal transducer beta-catenin controls fibronectin expression. Mol Cell Biol 19: 55765587.
  • Gregorieff A, Pinto D, Begthel H, Destree O, Kielman M, Clevers H. 2005. Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology 129: 626638.
  • Hlubek F, Jung A, Kotzor N, Kirchner T, Brabletz T. 2001. Expression of the invasion factor laminin gamma2 in colorectal carcinomas is regulated by beta-catenin. Cancer Res 61: 80898093.
  • Hlubek F, Spaderna S, Jung A, Kirchner T, Brabletz T. 2004. Beta-catenin activates a coordinated expression of the proinvasive factors laminin-5 gamma2 chain and MT1-MMP in colorectal carcinomas. Int J Cancer 108: 321326.
  • Hlubek F, Pfeiffer S, Budczies J, Spaderna S, Jung A, Kirchner T, Brabletz T. 2006. Securin (hPTTG1) expression is regulated by beta-catenin/TCF in human colorectal carcinoma. Br J Cancer 94: 16721677.
  • Hlubek F, Brabletz T, Budczies J, Pfeiffer S, Jung A, Kirchner T. 2007. Heterogeneous expression of Wnt/beta-catenin target genes within colorectal cancer. Int J Cancer 121: 19411948.
  • Jung A, Schrauder M, Oswald U, Knoll C, Sellberg P, Palmqvist R, Niedobitek G, Brabletz T, Kirchner T. 2001. The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear beta-catenin, cyclin D1, and p16INK4A and is a region of low proliferation. Am J Pathol 159: 16131617.
  • Kinzler KW, Vogelstein B. 1996. Lessons from hereditary colorectal cancer. Cell 87: 159170.
  • Kirchner T, Brabletz T. 2000. Patterning and nuclear beta-catenin expression in the colonic adenoma- carcinoma sequence. Analogies with embryonic gastrulation. Am J Pathol 157: 11131121.
  • Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, Vogelstein B, Clevers H. 1997. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science 275: 17841787.
  • Liu W, Dong X, Mai M, Seelan RS, Taniguchi K, Krishnadath KK, Halling KC, Cunningham JM, Boardman LA, Qian C, Christensen E, Schmidt SS, Roche PC, Smith DI, Thibodeau SN. 2000. Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling. Nat Genet 26: 146147.
  • Mariadason JM, Nicholas C, L'Italien KE, Zhuang M, Smartt HJ, Heerdt BG, Yang W, Corner GA, Wilson AJ, Klampfer L, Arango D, Augenlicht LH. 2005. Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis. Gastroenterology 128: 10811088.
  • Melchior K, Weiss J, Zaehres H, Kim YM, Lutzko C, Roosta N, Hescheler J, Muschen M. 2008. The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cells. Biol Chem 389: 897903.
  • Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, Kinzler KW. 1997. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275: 17871790.
  • Munoz R, Moreno M, Oliva C, Orbenes C, Larrain J. 2006. Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos. Nat Cell Biol 8: 492500.
  • Pouliot N, Burgess AW. 2000. Multiple autocrine factors including an extracellular matrix protein are required for the proliferation and spreading of human colon carcinoma cells in vitro. Growth Factors 18: 3149.
  • Sagara N, Toda G, Hirai M, Terada M, Katoh M. 1998. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. Biochem Biophys Res Commun 252: 117122.
  • Schmalhofer O, Spaderna S, Brabletz T. 2008. Native promoter reporters validate transcriptional targets. Methods Mol Biol 468: 111128.
  • Spaderna S, Schmalhofer O, Wahlbuhl M, Dimmler A, Bauer K, Sultan A, Hlubek F, Jung A, Strand D, Eger A, Kirchner T, Behrens J, Brabletz T. 2008. The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. Cancer Res 68: 537544.
  • Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Dong Chen W, Pretlow TP, Yang B, Akiyama Y, Van Engeland M, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG, Baylin SB. 2004. Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 36: 417422.
  • Taniguchi H, Yamamoto H, Hirata T, Miyamoto N, Oki M, Nosho K, Adachi Y, Endo T, Imai K, Shinomura Y. 2005. Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers. Oncogene 24: 79467952.
  • Ueno K, Hiura M, Suehiro Y, Hazama S, Hirata H, Oka M, Imai K, Dahiya R, Hinoda Y. 2008. Frizzled-7 as a potential therapeutic target in colorectal cancer. Neoplasia 10: 697705.
  • van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, van der Horn K, Batlle E, Coudreuse D, Haramis AP, Tjon-Pon-Fong M, Moerer P, van den Born M, Soete G, Pals S, Eilers M, Medema R, Clevers H. 2002. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111: 241250.
  • Vijayaragavan K, Szabo E, Bosse M, Ramos-Mejia V, Moon RT, Bhatia M. 2009. Noncanonical Wnt signaling orchestrates early developmental events toward hematopoietic cell fate from human embryonic stem cells. Cell Stem Cell 4: 248262.
  • Vincan E. 2004. Frizzled/WNT signalling: the insidious promoter of tumour growth and progression. Front Biosci 9: 10231034.
  • Vincan E, Barker N. 2008. The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression. Clin Exp Metastasis 25: 657663.
  • Vincan E, Brabletz T, Faux MC, Ramsay RG. 2007a. A human three-dimensional cell line model allows the study of dynamic and reversible epithelial-mesenchymal and mesenchymal-epithelial transition that underpins colorectal carcinogenesis. Cells Tissues Organs 185: 2028.
  • Vincan E, Darcy PK, Farrelly CA, Faux MC, Brabletz T, Ramsay RG. 2007b. Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids. Oncogene 26: 23402352.
  • Wassermann S, Scheel SK, Hiendlmeyer E, Palmqvist R, Horst D, Hlubek F, Haynl A, Kriegl L, Reu S, Merkel S, Brabletz T, Kirchner T, Jung A. 2009. p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors. Gastroenterology 136: 196205.
  • Willert J, Epping M, Pollack JR, Brown PO, Nusse R. 2002. A transcriptional response to Wnt protein in human embryonic carcinoma cells. BMC Dev Biol 2: 815.