Special Issue Reviews–A Peer Reviewed Forum
Interactions between SOX factors and Wnt/β-catenin signaling in development and disease
Article first published online: 4 AUG 2009
Copyright © 2009 Wiley-Liss, Inc.
Special Issue: Special Issue on WNT Signaling in Development and Disease
Volume 239, Issue 1, pages 56–68, January 2010
How to Cite
Kormish, J. D., Sinner, D. and Zorn, A. M. (2010), Interactions between SOX factors and Wnt/β-catenin signaling in development and disease. Dev. Dyn., 239: 56–68. doi: 10.1002/dvdy.22046
- Issue published online: 15 DEC 2009
- Article first published online: 4 AUG 2009
- Manuscript Accepted: 24 JUN 2009
- NIH. Grant Numbers: HD42572, DK70858, T32 HD046387
The SOX family of transcription factors have emerged as modulators of canonical Wnt/β-catenin signaling in diverse development and disease contexts. There are over 20 SOX proteins encoded in the vertebrate genome and recent evidence suggests that many of these can physically interact with β-catenin and modulate the transcription of Wnt-target genes. The precise mechanisms by which SOX proteins regulate β-catenin/TCF activity are still being resolved and there is evidence to support a number of models including: protein–protein interactions, the binding of SOX factors to Wnt-target gene promoters, the recruitment of co-repressors or co-activators, modulation of protein stability, and nuclear translocation. In some contexts, Wnt signaling also regulates SOX expression resulting in feedback regulatory loops that fine-tune cellular responses to β-catenin/TCF activity. In this review, we summarize the examples of Sox–Wnt interactions and examine the underlying mechanisms of this potentially widespread and underappreciated mode of Wnt-regulation. Developmental Dynamics 239:56–68, 2010. © 2009 Wiley-Liss, Inc.