Patterns & Phenotypes
Postembryonic fast muscle growth of teleost fish depends upon a nonuniformly distributed population of mitotically active Pax7+ precursor cells
Article first published online: 3 AUG 2009
Copyright © 2009 Wiley-Liss, Inc.
Special Issue: Special Focus on Visual Systems
Volume 238, Issue 9, pages 2442–2448, September 2009
How to Cite
Marschallinger, J., Obermayer, A., Sänger, A.M., Stoiber, W. and Steinbacher, P. (2009), Postembryonic fast muscle growth of teleost fish depends upon a nonuniformly distributed population of mitotically active Pax7+ precursor cells. Dev. Dyn., 238: 2442–2448. doi: 10.1002/dvdy.22049
- Issue published online: 13 AUG 2009
- Article first published online: 3 AUG 2009
- Manuscript Accepted: 25 JUN 2009
- Austrian Science Foundation (FWF). Grant Number: P20430
- myogenic precursor;
- fish muscle;
Muscle development in teleost embryos has been shown to depend on myogenic cell recruitment from the dermomyotome (DM). However, little is known as to the cellular mechanisms that account for myotome growth after the dissociation of the DM. Here we combine immunolabeling for cell-specific markers with quantitative analysis to determine the sources and patterns of activation of myogenic cells in pearlfish larvae. Results demonstrate that appearance of mitotically active myogenic precursors inside the myotome coincides with the dissociation of the DM. Such cells are preferentially aggregated within the posterior lateral fast muscle. We therefore propose a growth model in which a pool of proliferative DM-derived precursors transferred to the posterior lateral fast muscle functions as an important source of myogenic cell spread to carry forward stratified fast muscle hyperplasia. This indicates that postembryonic teleost muscle growth includes a cellular mechanism that has no direct equivalent in the amniotes. Developmental Dynamics 238:2442–2448, 2009. © 2009 Wiley-Liss, Inc.