Special Issue Research Article
A study on the interactions between heparan sulfate proteoglycans and Wnt proteins
Article first published online: 24 AUG 2009
Copyright © 2009 Wiley-Liss, Inc.
Special Issue: Special Issue on WNT Signaling in Development and Disease
Volume 239, Issue 1, pages 184–190, January 2010
How to Cite
Fuerer, C., Habib, S. J. and Nusse, R. (2010), A study on the interactions between heparan sulfate proteoglycans and Wnt proteins. Dev. Dyn., 239: 184–190. doi: 10.1002/dvdy.22067
- Issue published online: 15 DEC 2009
- Article first published online: 24 AUG 2009
- Manuscript Accepted: 12 JUL 2009
- Howard Hughes Medical Institute
- California Institute of Regenerative Medicine. Grant Number: RC1-00133-1
- Swiss National Science Foundation. Grant Number: PA00A3-115379
- The German Research Foundation
The Wnt signaling pathway plays key roles in development and adult homeostasis. Wnt proteins are secreted, lipid-modified glycoproteins. They can form morphogen gradients that are regulated at the level of protein secretion, diffusion, and internalization. These gradients can only exist if the hydrophobic Wnt proteins are prevented from aggregating in the extracellular environment. Heparan sulfate proteoglycans (HSPGs) are necessary for proper activity of Wnt proteins and influence their distribution along the morphogenetic gradient. In this study, we show that HSPGs are able to maintain the solubility of Wnt proteins, thus stabilizing their signaling activity. Our results suggest that the role of HSPGs is not only to concentrate Wnt molecules at the cell surface but also to prevent them from aggregating in the extracellular environment. Developmental Dynamics 239:184–190, 2009. © 2009 Wiley-Liss, Inc.