Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development

Authors

  • Branden R. Nelson,

    1. Department of Biological Structure, School of Medicine, University of Washington, Seattle, Washington
    Current affiliation:
    1. Center for Neuroscience, Seattle Children's Research Institute, 1900 Ninth Avenue, MS C9S-8, Seattle, WA 98101
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  • Byron H. Hartman,

    1. Department of Biological Structure, School of Medicine, University of Washington, Seattle, Washington
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  • Catherine A. Ray,

    1. Department of Biological Structure, School of Medicine, University of Washington, Seattle, Washington
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  • Toshinori Hayashi,

    1. Department of Biological Structure, School of Medicine, University of Washington, Seattle, Washington
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  • Olivia Bermingham-McDonough,

    1. Department of Biological Structure, School of Medicine, University of Washington, Seattle, Washington
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  • Thomas A. Reh

    Corresponding author
    1. Department of Biological Structure, School of Medicine, University of Washington, Seattle, Washington
    • Department of Biological Structure, School of Medicine, University of Washington, Seattle, WA 98195
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Abstract

Retinascape: Multiphoton microscopy was used to look deep into the retina, at the dawn of neurogenesis in the embryonic mouse eye: mitotic progenitors (anti-phosphohistone H3, green) and newborn neurons (beta-III tubulin Tuj1, red). View is of new neurons originating in the central neurogenic domain of the embryonic day 12 (E12) retina surrounded by mitotic progenitors, viewed from within an older E14.5 retina. New data from Nelson and colleagues (pages 2163–2178, this issue) reveals that in addition to Notch and Ascl1, mammalian retinal progenitors also express multiple Delta-like genes, and that a conserved Ascl1/Delta-like/Notch/Hes molecular circuitry operates between progenitors themselves to coordincate retinal histogenesis. From Nelson et al., Developmental Dynamics 238:2163–2178, 2009. © 2009 Wiley-Liss, Inc.

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