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Special Issue Reviews-A Peer Reviewed Forum
Wnt modulators in the biotech pipeline
Article first published online: 11 DEC 2009
DOI: 10.1002/dvdy.22181
Copyright © 2009 Wiley-Liss, Inc.
Issue
Developmental Dynamics
Special Issue: Special Issue on WNT Signaling in Development and Disease
Volume 239, Issue 1, pages 102–114, January 2010
Additional Information
How to Cite
Rey, J.-P. and Ellies, D. L. (2010), Wnt modulators in the biotech pipeline. Dev. Dyn., 239: 102–114. doi: 10.1002/dvdy.22181
Publication History
- Issue published online: 15 DEC 2009
- Article first published online: 11 DEC 2009
- Manuscript Accepted: 30 OCT 2009
Funded by
- Kansas Bioscience Authority
- US Department of Health and Human Services
- National Institute of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Erratum: Wnt modulators in the biotech pipeline
Vol. 239, Issue 3, 1034, Article first published online: 28 JAN 2010
- Abstract
- Article
- References
- Cited By
Keywords:
- Wnt;
- Sclerostin;
- CCN;
- SOSTDC1;
- LRP;
- Mucin;
- DAN;
- Norrin;
- PDGF;
- VEGF;
- cystine knot;
- cystein domain;
- bone;
- CTGF;
- VWF;
- Wise;
- Ectodin;
- therapeutics;
- Slit
Abstract
The purpose of this review is to provide a better understanding for the LRP co-receptor-mediated Wnt pathway signaling. Using proteomics, we have also subdivided the LRP receptor family into six sub-families, encompassing the twelve family members. This review includes a discussion of proteins containing a cystine-knot protein motif (i.e., Sclerostin, Dan, Sostdc1, Vwf, Norrin, Pdgf, Mucin) and discusses how this motif plays a role in mediating Wnt signaling through interactions with LRP. Developmental Dynamics 239:102–114, 2010. © 2009 Wiley-Liss, Inc.