Patterns & Phenotypes
Retinoic acid controls expression of tissue remodeling genes Hmgn1 and Fgf18 at the digit–interdigit junction
Article first published online: 23 DEC 2009
Copyright © 2009 Wiley-Liss, Inc.
Volume 239, Issue 2, pages 665–671, February 2010
How to Cite
Zhao, X., Brade, T., Cunningham, T. J. and Duester, G. (2010), Retinoic acid controls expression of tissue remodeling genes Hmgn1 and Fgf18 at the digit–interdigit junction. Dev. Dyn., 239: 665–671. doi: 10.1002/dvdy.22188
- Issue published online: 22 JAN 2010
- Article first published online: 23 DEC 2009
- Manuscript Accepted: 10 NOV 2009
- The National Institutes of Health. Grant Number: GM062848
- 2005. Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2. Matrix Biol 24: 247–260. , , , , , , , , , .
- 1999. Sox9 is required for cartilage formation. Nat Genet 22: 85–89. , , , , .
- 1988. Inhibition of chondrogenesis by retinoic acid in limb mesenchymal cells in vitro: effects on PGE2 and cyclic AMP concentrations. Cell Differ Dev 25: 65–75. , , , .
- 2008. Retinoic acid synthesis and signaling during early organogenesis. Cell 134: 921–931. .
- 1999. Essential roles of retinoic acid signaling in interdigital apoptosis and control of BMP-7 expression in mouse autopods. Dev Biol 208: 30–43. , , , , , , .
- 2006. Down-regulation of nucleosomal binding protein HMGN1 expression during embryogenesis modulates Sox9 expression in chondrocytes. Mol Cell Biol 26: 592–604. , , , , , .
- 1997. Role of the retinoic acid receptor beta (RARb) during mouse development. Int J Dev Biol 41: 425–447. , , , , , , , .
- 1990. A retinoic acid receptor-specific element controls the retinoic acid receptor-beta promoter. Mol Endocrinol 4: 1727–1736. , , , , , , .
- 1994. Manipulating the mouse embryo, 2nd edition. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory. , , , .
- 2009. Mutant Hoxd13 induces extra digits in a mouse model of synpolydactyly directly and by decreasing retinoic acid synthesis. J Clin Invest 119: 146–156. , , , , , , , .
- 2008. Restriction of retinoic acid activity by Cyp26b1 is required for proper timing and patterning of osteogenesis during zebrafish development. Development 135: 3775– 3787. , , , , .
- 2002. Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. Genes Dev 16: 859–869. , , , .
- 2009. In the limb AER Bmp2 and Bmp4 are required for dorsal-ventral patterning and interdigital cell death but not limb outgrowth. Dev Biol 327: 516–523. , , , .
- 2001. Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26b1, and comparative expression analysis with Cyp26A1 during early murine development. Mech Dev 107: 195–201. , , , , , .
- 2009. Genetic disruption of CYP26B1 severely affects development of neural crest derived head structures, but does not compromise hindbrain patterning. Dev Dyn 238: 732–745. , , .
- 1997. Msx2 is a transcriptional regulator in the BMP4-mediated programmed cell death pathway. Dev Biol 186: 127–138. , , .
- 1991. Developmental analysis of the retinoic acid-inducible RAR-beta 2 promoter in transgenic animals. Development 113: 723–734. , , , , .
- 2002. Novel retinoic acid generating activities in the neural tube and heart identified by conditional rescue of Raldh2 null mutant mice. Development 129: 2271–2282. , , , .
- 1997. Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development. Mech Dev 62: 67–78. , , , , .
- 1999. Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nat Genet 21: 444–448. , , , .
- 2001. Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse. Development 128: 1019– 1031. , , , , , .
- 2007. BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling. Development 134: 2359–2368. , , , , .
- 1991. Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis. Genes Dev 5: 1333– 1344. , , , , .
- 2000. Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. Nat Genet 24: 391–395. , , , , , , , , , , , , , .
- 2005. Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo. Science 308: 563–566. , , , , , .
- 2009. Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse. Dev Biol 328: 315–327. , , , , , , , , , , , , , , , .
- 2009. Effect of retinoic acid signaling on Wnt/b-catenin and FGF signaling during body axis extension. Gene Expr Patterns 9: 430–435. , .
- 2009. Retinoic acid promotes limb induction through effects on body axis extension but is unnecessary for limb patterning. Curr Biol 19: 1050–1057. , , , , , , .