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Keywords:

  • DAF-16;
  • FOXO;
  • DAF-2;
  • insulin;
  • aging;
  • longevity;
  • C. elegans

Abstract

In a remarkably conserved insulin signaling pathway that is well-known for its regulation of longevity in worms, flies, and mammals, the major C. elegans effector of this pathway, DAF-16/FOXO, also modulates many other physiological processes. This raises the question of how DAF-16/FOXO chooses the correct targets to achieve the appropriate response in a particular context. Here, we review current knowledge of tissue-specificity and interacting partners that modulate DAF-16/FOXO functional output. Developmental Dynamics 239:1405–1412, 2010. © 2010 Wiley-Liss, Inc.