Special Issue Reviews-A Peer Reviewed Forum
Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO
Article first published online: 5 FEB 2010
Copyright © 2010 Wiley-Liss, Inc.
Special Issue: Special Issue on Caenorhabditis elegans
Volume 239, Issue 5, pages 1405–1412, May 2010
How to Cite
Landis, J. N. and Murphy, C. T. (2010), Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO. Dev. Dyn., 239: 1405–1412. doi: 10.1002/dvdy.22244
- Issue published online: 13 APR 2010
- Article first published online: 5 FEB 2010
- Manuscript Accepted: 5 JAN 2010
- C. elegans
In a remarkably conserved insulin signaling pathway that is well-known for its regulation of longevity in worms, flies, and mammals, the major C. elegans effector of this pathway, DAF-16/FOXO, also modulates many other physiological processes. This raises the question of how DAF-16/FOXO chooses the correct targets to achieve the appropriate response in a particular context. Here, we review current knowledge of tissue-specificity and interacting partners that modulate DAF-16/FOXO functional output. Developmental Dynamics 239:1405–1412, 2010. © 2010 Wiley-Liss, Inc.