Patterns & Phenotypes
Generation and characterization of a novel neural crest marker allele, Inka1-LacZ, reveals a role for Inka1 in mouse neural tube closure
Version of Record online: 19 FEB 2010
Copyright © 2010 Wiley-Liss, Inc.
Volume 239, Issue 4, pages 1188–1196, April 2010
How to Cite
Reid, B. S., Sargent, T. D. and Williams, T. (2010), Generation and characterization of a novel neural crest marker allele, Inka1-LacZ, reveals a role for Inka1 in mouse neural tube closure. Dev. Dyn., 239: 1188–1196. doi: 10.1002/dvdy.22248
- Issue online: 16 MAR 2010
- Version of Record online: 19 FEB 2010
- Manuscript Accepted: 13 JAN 2010
- NIDCR. Grant Number: DE12728
Additional Supporting Information may be found in the online version of this article.
|DVDY_22248_sm_SuppinfoFigS1.tif||925K||Supp. Fig. S1. Additional expression analysis of the Inka1-LacZ allele. A, B: Whole-mount X-gal stained E8.0 embryos shown in ventral (A) and dorsal (B) views. Numbered lines indicate planes of sections shown in Figure 3A–D. C, D: Sagittal sections of E15.5 embryos stained with X-gal and counterstained with nuclear fast red. cp, choroid plexus; drg, dorsal root ganglia; mf, mesencephalic flexure; nsp, nasopharanyx; orp, oropharanyx; pit, pituitary; ttr, tubo-tympanic recess; v, vertebrae.|
|DVDY_22248_sm_SuppinfoFigS2.tif||1875K||Supp. Fig. S2. Neural crest migration and derivatives in Inka1−/− mice. A,B: Lateral views of Tcfap2a RNA expression in E9.5 wild-type (A) and Inka1−/− embryos (B). C,D: Lateral views of E10.5 wild-type (C) and Inka1−/− embryos (D) stained for neurofilament to show peripheral nervous system. cg, cranial ganglia; drg, dorsal root ganglia; tg, trigeminal ganglia. Numbers 7–10 indicate cranial nerves.|
|DVDY_22248_sm_SuppinfoFigS3.tif||2665K||Supp. Fig. S3. Skeletal analysis of Inka1−/− mice. A–D: Skeletal stains of wild-type (A, C) and Inka1 null (B, D) mice shown in norma verticalis (A, B) and dorsal (C, D) views. E, F: Alcian blue cartilage stains of E15.5 wild-type (E) and Inka1 null (F) forelimbs. a, anterior; hl, hindlimb; ip, interparietal; n, nasal bone; p, posterior; pr, parietal; r, ribs; rd, radius; u, ulna; v, vertebrae; z, zygomatic.|
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