• Open Access

Caenorhabditis elegans: A new model organism for studies of axon regeneration

Authors

  • Anindya Ghosh-Roy,

    1. Division of Biological Sciences, Section of Neurobiology, University of California San Diego, La Jolla, California
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  • Andrew D. Chisholm

    Corresponding author
    1. Division of Biological Sciences, Section of Neurobiology, University of California San Diego, La Jolla, California
    • Division of Biological Sciences, Section of Neurobiology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093
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Abstract

Axonal regeneration in Caenorhabditis elegans was first reported five years ago. Individual green fluorescent protein-labeled axons can be severed using laser microsurgery and their regrowth followed in vivo. Several neuron types display robust regrowth after injury, including motor and sensory neurons. The small size and transparency of C. elegans make possible large-scale genetic and pharmacological screens for regeneration phenotypes. Developmental Dynamics 239:1460–1464, 2010. © 2010 Wiley-Liss, Inc.

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