Special Issue Reviews-A Peer Reviewed Forum
Soma-germline interactions that influence germline proliferation in Caenorhabditis elegans
Article first published online: 11 MAR 2010
Copyright © 2010 Wiley-Liss, Inc.
Special Issue: Special Issue on Caenorhabditis elegans
Volume 239, Issue 5, pages 1449–1459, May 2010
How to Cite
Korta, D. Z. and Hubbard, E. J. A. (2010), Soma-germline interactions that influence germline proliferation in Caenorhabditis elegans. Dev. Dyn., 239: 1449–1459. doi: 10.1002/dvdy.22268
- Issue published online: 13 APR 2010
- Article first published online: 11 MAR 2010
- Manuscript Accepted: 4 JAN 2010
- NIH. Grant Number: GM61706
- L1 diapause;
Caenorhabditis elegans boasts a short lifecycle and high fecundity, two features that make it an attractive and powerful genetic model organism. Several recent studies indicate that germline proliferation, a prerequisite to optimal fecundity, is tightly controlled over the course of development. Cell proliferation control includes regulation of competence to proliferate, a poorly understood aspect of cell fate specification, as well as cell-cycle control. Furthermore, dynamic regulation of cell proliferation occurs in response to multiple external signals. The C. elegans germ line is proving a valuable model for linking genetic, developmental, systemic, and environmental control of cell proliferation. Here, we consider recent studies that contribute to our understanding of germ cell proliferation in C. elegans. We focus primarily on somatic control of germline proliferation, how it differs at different life stages, and how it can be altered in the context of the life cycle and changes in environmental status. Developmental Dynamics 239:1449–1459, 2010. © 2010 Wiley-Liss, Inc.