Special Issue Reviews-A Peer Reviewed Forum
“CRASH”ing with the worm: Insights into L1CAM functions and mechanisms
Article first published online: 11 MAR 2010
Copyright © 2010 Wiley-Liss, Inc.
Special Issue: Special Issue on Caenorhabditis elegans
Volume 239, Issue 5, pages 1490–1501, May 2010
How to Cite
Chen, L. and Zhou, S. (2010), “CRASH”ing with the worm: Insights into L1CAM functions and mechanisms. Dev. Dyn., 239: 1490–1501. doi: 10.1002/dvdy.22269
- Issue published online: 13 APR 2010
- Article first published online: 11 MAR 2010
- Manuscript Accepted: 29 JAN 2010
- National Institute of Neurological Disorders and Stroke. Grant Number: NS045873
- C. elegans;
- axon guidance;
- neural maintenance
The L1 family of cell adhesion molecules (L1CAMs) in vertebrates has long been studied for its roles in nervous system development and function. Members of this family have been associated with distinct neurological disorders that include CRASH, autism, 3p syndrome, and schizophrenia. The conservation of L1CAMs in Drosophila and Caenorhabditis elegans allows the opportunity to take advantage of these simple model organisms and their accessible genetic manipulations to dissect L1CAM functions and mechanisms of action. This review summarizes the discoveries of L1CAMs made in C. elegans, showcasing this simple model organism as a powerful system to uncover L1CAM mechanisms and roles in healthy and diseased states. Developmental Dynamics 239:1490–1501, 2010. © 2010 Wiley-Liss, Inc.