Patterns & Phenotypes
Expression of seven members of the ADAM family in developing chicken spinal cord
Article first published online: 16 MAR 2010
Copyright © 2010 Wiley-Liss, Inc.
Volume 239, Issue 4, pages 1246–1254, April 2010
How to Cite
Lin, J., Yan, X., Markus, A., Redies, C., Rolfs, A. and Luo, J. (2010), Expression of seven members of the ADAM family in developing chicken spinal cord. Dev. Dyn., 239: 1246–1254. doi: 10.1002/dvdy.22272
- Issue published online: 16 MAR 2010
- Article first published online: 16 MAR 2010
- Manuscript Accepted: 15 FEB 2010
- German Research Foundation (DFG). Grant Number: LU 1455/1-1
- spinal cord;
- gene expression;
- chicken development
The expression patterns of seven members of the ADAM (a disintegrin and metalloprotease) family, including ADAM9, ADAM10, ADAM12, ADAM13, ADAM17, ADAM22, and ADAM23, were analyzed in the developing chicken lumbar spinal cord by in situ hybridization and immunohistochemistry. Results show that each individual ADAM is expressed and regulated spatiotemporally in the lumbar cord and its surrounding tissues. ADAM9, ADAM10, ADAM22, and ADAM23 are expressed predominantly by motoneurons in the motor column and by sensory neurons in the dorsal root ganglia, each with a different expression pattern. ADAM12 and ADAM13 are mainly expressed in the meninges around the lumbar cord and in the condensed sheets of chondroblasts around the vertebrae. ADAM17 expression is strong in the ventricular layer and limited to early stages. The differential expression of the ADAMs in the lumbar cord suggests that the ADAMs play a regulatory role in development of the spinal cord. Developmental Dynamics 239:1246–1254, 2010. © 2010 Wiley-Liss, Inc.