Fusion of uniluminal vascular spheroids: A model for assembly of blood vessels

Authors

  • Paul A. Fleming,

    1. Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina
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  • W. Scott Argraves,

    1. Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina
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  • Carmine Gentile,

    1. Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina
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  • Adrian Neagu,

    1. Victor Babes University of Medicine and Pharmacy Timisoara, Timisoara, Romania
    2. Department of Physics and Biology, University of Missouri Columbia, Missouri
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  • Gabor Forgacs,

    1. Department of Physics and Biology, University of Missouri Columbia, Missouri
    2. Department of Biological Sciences, University of Missouri Columbia, Missouri
    3. Department of Biomedical Engineering, University of Missouri Columbia, Missouri
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  • Christopher J. Drake

    Corresponding author
    1. Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina
    • Department of Cell Biology and Anatomy, Charleston, SC 29425
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Abstract

Zebrafish Intrahepatic Biliary System: Confocal projection through the liver of a 5 day post-fertilization zebrafish larva immunostained with antibodies raised against the human multidrug resistance protein-1 (red), also known as Pglcyoprotein, an ABC transporter in the hepatocyte canalicular membrane, and a novel zebrafish epitope 2F11 (green) that recognizes biliary epithelial cells. Hepatocytes secrete bile through their canaliculus into the intrahepatic biliary duct network. 10 μm z-stack. From Lorent et al., Developmental Dynamics 239:398-406, 2010.

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