A. Ni and E. Lashnits contributed equally to this work.
Rapid remodeling of airway vascular architecture at birth
Article first published online: 20 AUG 2010
Copyright © 2010 Wiley-Liss, Inc.
Volume 239, Issue 9, pages 2354–2366, September 2010
How to Cite
Ni, A., Lashnits, E., Yao, L.-C., Baluk, P. and McDonald, D. M. (2010), Rapid remodeling of airway vascular architecture at birth. Dev. Dyn., 239: 2354–2366. doi: 10.1002/dvdy.22379
- Issue published online: 24 AUG 2010
- Article first published online: 20 AUG 2010
- Manuscript Accepted: 29 JUN 2010
- National Institutes of Health. Grant Numbers: HL24136, HL59157, HL96511
- National Cancer Institute. Grant Number: CA82923
- AngelWorks Foundation
- respiratory tract;
- blood vessels;
- vascular regression;
Recent advances have documented the development of lung vasculature before and after birth, but less is known of the growth and maturation of airway vasculature. We sought to determine whether airway vasculature changes during the perinatal period and when the typical adult pattern develops. On embryonic day 16.5 mouse tracheas had a primitive vascular plexus unlike the adult airway vasculature, but instead resembling the yolk sac vasculature. Soon after birth (P0), the primitive vascular plexus underwent abrupt and extensive remodeling. Blood vessels overlying tracheal cartilage rings regressed from P1 to P3 but regrew from P4 to P7 to form the hierarchical, segmented, ladder-like adult pattern. Hypoxia and HIF-1α were present in tracheal epithelium over vessels that survived but not where they regressed. These findings reveal the plasticity of airway vasculature after birth and show that these vessels can be used to elucidate factors that promote postnatal vascular remodeling and maturation. Developmental Dynamics 239:2354–2366, 2010. © 2010 Wiley-Liss, Inc.