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Far from solved: A perspective on what we know about early mechanisms of left–right asymmetry
Article first published online: 28 OCT 2010
Copyright © 2010 Wiley-Liss, Inc.
Volume 239, Issue 12, pages 3131–3146, December 2010
How to Cite
Vandenberg, L. N. and Levin, M. (2010), Far from solved: A perspective on what we know about early mechanisms of left–right asymmetry. Dev. Dyn., 239: 3131–3146. doi: 10.1002/dvdy.22450
- Issue published online: 22 NOV 2010
- Article first published online: 28 OCT 2010
- Manuscript Accepted: 11 SEP 2010
- American Heart Association. Grant Number: Established Investigator Grant 0740088N
- The National Institutes of Health. Grant Numbers: R01-GM077425, 1F32GM087107-01
- left–right asymmetry;
- nodal flow
Consistent laterality is a crucial aspect of embryonic development, physiology, and behavior. While strides have been made in understanding unilaterally expressed genes and the asymmetries of organogenesis, early mechanisms are still poorly understood. One popular model centers on the structure and function of motile cilia and subsequent chiral extracellular fluid flow during gastrulation. Alternative models focus on intracellular roles of the cytoskeleton in driving asymmetries of physiological signals or asymmetric chromatid segregation, at much earlier stages. All three models trace the origin of asymmetry back to the chirality of cytoskeletal organizing centers, but significant controversy exists about how this intracellular chirality is amplified onto cell fields. Analysis of specific predictions of each model and crucial recent data on new mutants suggest that ciliary function may not be a broadly conserved, initiating event in left–right patterning. Many questions about embryonic left–right asymmetry remain open, offering fascinating avenues for further research in cell, developmental, and evolutionary biology. Developmental Dynamics 239:3131–3146, 2010. © 2010 Wiley-Liss, Inc.