Patterns & Phenotypes
GPR56 is essential for testis development and male fertility in mice
Version of Record online: 27 OCT 2010
Copyright © 2010 Wiley-Liss, Inc.
Volume 239, Issue 12, pages 3358–3367, December 2010
How to Cite
Chen, G., Yang, L., Begum, S. and Xu, L. (2010), GPR56 is essential for testis development and male fertility in mice. Dev. Dyn., 239: 3358–3367. doi: 10.1002/dvdy.22468
- Issue online: 22 NOV 2010
- Version of Record online: 27 OCT 2010
- Manuscript Accepted: 27 SEP 2010
- Howard Hughes Medical Institute
- NIH. Grant Number: U54-CA126515
- University of Rochester
- Ruth L. Kirschstein National Research Service Award
- seminiferous tubules;
Testis development is critical for male fertility and continuation of the mammalian species. Essential structural components of testes are seminiferous tubules, which are lined by Sertoli cells and provide nutrients and physical protection for the maturation of sperm. Seminiferous tubule formation is initiated in embryos as testis cords and relies on their remodeling for maturation during development. Recently, three-dimensional image analyses showed that testis cords in different parts of embryonic gonads undergo distinct remodeling processes. How this asymmetric remodeling is regulated has not been investigated. We report here that the absence of an adhesion G protein-coupled receptor, GPR56, leads to partial disruption of seminiferous tubules and reduced fertility in male mice. The defects appear to originate asymmetrically in embryonic gonads, but subsequent to the initial establishment of testis cords, suggesting that GPR56 might act to establish a spatial and/or temporal cue for asymmetric cord remodeling during male gonad development. Developmental Dynamics 239:3358–3367, 2010. © 2010 Wiley-Liss, Inc.