Special Issue Reviews–A Peer Reviewed Forum
The building blocks of mammalian lung development
Article first published online: 18 NOV 2010
Copyright © 2010 Wiley-Liss, Inc.
Special Issue: Special Focus on Endoderm
Volume 240, Issue 3, pages 463–476, March 2011
How to Cite
Rawlins, E. L. (2011), The building blocks of mammalian lung development. Dev. Dyn., 240: 463–476. doi: 10.1002/dvdy.22482
- Issue published online: 17 FEB 2011
- Article first published online: 18 NOV 2010
- Manuscript Accepted: 1 OCT 2010
- MRC. Grant Number: GO900424
- progenitor cell;
- stem cell;
Progress has recently been made in identifying progenitor cell populations in the embryonic lung. Some progenitor cell types have been definitively identified by lineage-tracing studies. However, others are not as well characterized and their existence is inferred on the basis of lung morphology, or mutant phenotypes. Here, I focus on lung development after the specification of the initial lung primordium. The evidence for various lung embryonic progenitor cell types is discussed and future experiments are suggested. The regulation of progenitor proliferation in the embryonic lung, and its coordinate control with morphogenesis, is also discussed. In addition, the relationship between embryonic and adult lung progenitors is considered. Developmental Dynamics 240:463–476, 2011. © 2010 Wiley-Liss, Inc.