Drs. Ding and Wang contributed equally to this work.
Glial cell adhesive molecule unzipped mediates axon guidance in Drosophila
Article first published online: 29 NOV 2010
Copyright © 2010 Wiley-Liss, Inc.
Volume 240, Issue 1, pages 122–134, January 2011
How to Cite
Ding, Z.-Y., Wang, Y.-H., Luo, Z.-K., Lee, H.-F., Hwang, J., Chien, C.-T. and Huang, M.-L. (2011), Glial cell adhesive molecule unzipped mediates axon guidance in Drosophila. Dev. Dyn., 240: 122–134. doi: 10.1002/dvdy.22508
- Issue published online: 22 DEC 2010
- Article first published online: 29 NOV 2010
- Manuscript Accepted: 1 NOV 2010
- National Science Council of Taiwan. Grant Number: 95-2311-B-194-001-MY3
- axon guidance;
Axon guidance needs help from the glial cell system during embryogenesis. In the Drosophila embryonic central nervous system (CNS), longitudinal glia (LG) have been implicated in axon guidance but the mechanism remains unclear. We identified the protein encoded by the Drosophila gene unzipped (uzip) as a novel cell adhesion molecule (CAM). Uzip expressed in Drosophila S2 cells triggered cell aggregation through homophilic binding. In the embryonic CNS, Uzip was mainly produced by the LG but was also located at axons, which is consistent with the secretion of Uzip expressed in cultured cells. Although uzip mutants displayed no axonal defect, loss of uzip enhanced the axonal defects in the mutant of N-cadherin (CadN) and the Wnt gene family member wnt5. Overexpression of uzip could rescue the phenotype in the CadNuzipD43 mutant. Thus, Uzip is a novel CAM from the LG regulating axon guidance. Developmental Dynamics, 2011. © 2010 Wiley-Liss, Inc.