• Open Access

Far From Solved: A Perspective on What We Know About Early Mechanisms of Left–Right Asymmetry

Authors

  • Laura N. Vandenberg,

    1. Biology Department, and Tufts Center for Regenerative and Developmental Biology, Tufts University, Medford, Massachusetts
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  • Michael Levin

    Corresponding author
    1. Biology Department, and Tufts Center for Regenerative and Developmental Biology, Tufts University, Medford, Massachusetts
    • Biology Department, and Tufts Center for Regenerative and Developmental Biology, Tufts University, Suite 4600, 200 Boston Avenue, Medford, MA 02155
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Abstract

The frog embryo knows its left from its right as early as the first cell cleavage. Here, at the 2-cell stage, one blastomere was injected with the fluorescent dye Oregon Green, while the other blastomere was injected with Rhodamine. The resulting pattern in the mature tadpole reveals the concordance of the first cell division with the midplane of the bilaterally-symmetric vertebrate body-plan. From Vandenberg and Levin et al., Developmental Dynamics 239:3131–3146, 2010.

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