Long form of latent TGF-β binding protein 1 (Ltbp1L) regulates cardiac valve development
Version of Record online: 22 DEC 2010
Copyright © 2010 Wiley-Liss, Inc.
Volume 240, Issue 1, pages 176–187, January 2011
How to Cite
Todorovic, V., Finnegan, E., Freyer, L., Zilberberg, L., Ota, M. and Rifkin, D. B. (2011), Long form of latent TGF-β binding protein 1 (Ltbp1L) regulates cardiac valve development. Dev. Dyn., 240: 176–187. doi: 10.1002/dvdy.22521
- Issue online: 22 DEC 2010
- Version of Record online: 22 DEC 2010
- Manuscript Accepted: 11 NOV 2010
- NIH. Grant Numbers: R01CA34282, P01AR049698
Additional Supporting Information may be found in the online version of this article.
|DVDY_22521_sm_suppfig1.tif||1495K||Supp. Fig. S1. Proliferation and apoptotic index in E14.5 AVC valves. A: Proliferation index in E14.5 atrio-ventricular valves. Y axes represents the number of proliferating (phospho-histone 3-positive) mesenchymal cells per 1,000 cells within AV valves. Horizontal black bars represent the average number of proliferating mesenchymal cells for each valve and genotype. B: Apoptotic index in E14.5 mitral valves. Y axes represents the number of apoptotic (activated caspase 3-positive) mesenchymal cells per 1,000 cells within the mitral valves. Horizontal black bars represent the average number of apoptotic mesenchymal cells.|
|DVDY_22521_sm_suppfig2.tif||12571K||Supp. Fig. S2. Distribution of endothelial markers in E14.5 and E16.5 control and Ltbp1L mutants. Immunostainings for endothelial markers Pecam1 (A, A') and claudin 5 (B, B') of the endothelium lining dorsal aorta in E14.5 control (A) and Ltbp1L null (A') embryos and E16.5 control (B) and Ltbp1L mutant (B') mitral valves. Arrows indicate endothelium.|
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