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Beyond the Closed Suture in Apert Syndrome Mouse Models: Evidence of Primary Effects of FGFR2 Signaling on Facial Shape at Birth

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Abstract

Superimposed 3D visualization of the skull and head of mutant and non-mutant littermates of the FGFR2 P253R mouse model at birth (P0). Lateral views of skeletal bone reconstructed from μCT isosurfaces are displayed. Skin surfaces are visualized from volume renderings; red (top left): Fgfr2+/+ non-mutant littermate of the P253R model; and green (bottom right): Fgfr2+/P253R mutant littermate. From Martínez-Abadías et al., Developmental Dynamics 239:3058–3071, 2010.

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