Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development
Article first published online: 18 JAN 2011
Copyright © 2011 Wiley-Liss, Inc.
Volume 240, Issue 2, pages 372–383, February 2011
How to Cite
Dawe, C. E., Kooistra, M. K., Fairbridge, N. A., Pisio, A. C. and McDermid, H. E. (2011), Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development. Dev. Dyn., 240: 372–383. doi: 10.1002/dvdy.22547
- Issue published online: 18 JAN 2011
- Article first published online: 18 JAN 2011
- Manuscript Accepted: 15 DEC 2010
- Canadian Institutes of Health Research (CIHR). Grant Number: MOP64361
- inner ear defects;
- stereocilia bundles;
- planar cell polarity
The loss of Cecr2, which encodes a chromatin remodeling protein, has been associated with the neural tube defect (NTD) exencephaly and open eyelids in mice. Here, we show that two independent mutations of Cecr2 are also associated with specific inner ear defects. Homozygous mutant 18.5 days post coitus (dpc) fetuses exhibited smaller cochleae as well as rotational defects of sensory cells and extra cell rows in the inner ear reminiscent of planar cell polarity (PCP) mutants. Cecr2 was expressed in the neuroepithelium, head mesenchyme, and the cochlear floor. Although limited genetic interaction for NTDs was seen with Vangl2, a microarray analysis of PCP genes did not reveal a direct connection to this pathway. The mechanism of Cecr2 action in neurogenesis and inner ear development is likely complex. Developmental Dynamics 240:372–383, 2011. © 2011 Wiley-Liss, Inc.