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Primer and interviews: The dynamic stem cell niche
Article first published online: 14 FEB 2011
Copyright © 2011 Wiley-Liss, Inc.
Special Issue: Special Focus on Endoderm
Volume 240, Issue 3, pages 737–743, March 2011
How to Cite
Kiefer, J. C. (2011), Primer and interviews: The dynamic stem cell niche. Dev. Dyn., 240: 737–743. doi: 10.1002/dvdy.22566
- Issue published online: 17 FEB 2011
- Article first published online: 14 FEB 2011
- Manuscript Accepted: 10 JAN 2011
- stem cells;
- stem cell niche
A stem cell niche is a microenvironment that supports self-renewal of a population of stem cells, and their production of differentiated cells. While the definition evokes images of a stem cell Shangri-La—where a serene stem cell pool nestles within a niche that shelters and sustains it—the reality is much more tumultuous. Niches are subject to an ever-changing maelstrom of environmental factors, the ravages of old age, and the sly tactics of disease. Presented here is a basic overview of the different ways in which stem cell niches respond to local and systemic environments, and their impact on stem cell behavior. The primer culminates with a discussion of the topic with stem cell and niche biologists D. Leanne Jones, Ph.D., and Tudorita Tumbar, Ph.D. Developmental Dynamics 240:737–743, 2011. © 2011 Wiley-Liss, Inc.