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MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm

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Abstract

Low-density lipoprotein receptor family mediated endocytosis in the mouse visceral endoderm. Photo shows a whole mount view of a E7.5 wild-type embryo that was incubated with 50nM receptor associated protein (RAP) tagged with AlexaFluor 488 to visualize endocytosis in the visceral endoderm. Embryos were then fixed and counterstained with Alexa 594-Phalloidin to mark cell boundaries (color-corrected to magenta in Photoshop) and DAPI to mark nuclei (blue). From Lighthouse et al., Developmental Dynamics 240:577–588, 2011.

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