Jinping Shao and Dongyan Chen contributed equally to this article.
Special Issue Patterns & Phenotypes
Tissue regeneration after injury in adult zebrafish: The regenerative potential of the caudal fin
Article first published online: 15 MAR 2011
Copyright © 2011 Wiley-Liss, Inc.
Special Issue: Special Issue on Limb Development
Volume 240, Issue 5, pages 1271–1277, May 2011
How to Cite
Shao, J., Chen, D., Ye, Q., Cui, J., Li, Y. and Li, L. (2011), Tissue regeneration after injury in adult zebrafish: The regenerative potential of the caudal fin. Dev. Dyn., 240: 1271–1277. doi: 10.1002/dvdy.22603
- Issue published online: 20 APR 2011
- Article first published online: 15 MAR 2011
- Manuscript Accepted: 12 FEB 2011
- NIH. Grant Number: R01EY013147
- Chinese National Natural Science Foundation. Grant Number: 30970941
- Tianjin Science-Tech Committee. Grant Numbers: 08ZCKFSH04600, 08JCYBJC07100
- regeneration potential;
- caudal fin, marker gene expression
The zebrafish has the potential to regenerate many of its tissues. In this study, we examined caudal fin regeneration in zebrafish that received repeated injuries (fin amputation) at different ages. In zebrafish that received repeated injuries, the potential for caudal fin regeneration, such as tissue growth and the expression of regeneration marker genes (msxb, fgf20a, bmp2b), did not decline in comparison to zebrafish that received only one amputation surgery. The process of initial fin regeneration (e.g., tissue outgrowth and the expression of regeneration marker genes at 7 days post-amputation) did not seem to correlate with age. However, slight differences in fin outgrowth were observed between young and old animals when examined in the late regeneration stages (e.g., 20 and 30 days post-amputation). Together, the data suggest that zebrafish has unlimited regenerative potential in the injured caudal fin. Developmental Dynamics 240:1271–1277, 2011. © 2011 Wiley-Liss, Inc.