“Soft” tissue patterning: Muscles and tendons of the limb take their form

Authors

  • Peleg Hasson

    Corresponding author
    1. Department of Anatomy and Cell Biology, The Rappaport Family Institute for Research in the Medical Sciences, Technion-Israel Institute of Technology, Bat Galim, Haifa, Israel
    • Department of Anatomy and Cell Biology, The Rappaport Family Institute for Research in the Medical Sciences, Technion-Israel Institute of Technology, POB 9649, Bat Galim, Haifa 31096, Israel
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Abstract

The musculoskeletal system grants our bodies a vast range of movements. Because it is mainly composed of easily identifiable components, it serves as an ideal model to study patterning of the specific tissues that make up the organ. Surprisingly, although critical for the function of the musculoskeletal system, understanding of the embryonic processes that regulate muscle and tendon patterning is very limited. The recent identification of specific markers and the reagents stemming from them has revealed some of the molecular events regulating patterning of these soft tissues. This review will focus on some of the current work, with an emphasis on the roles of the muscle connective tissue, and discuss several key points that addressing them will advance our understanding of these patterning events. Developmental Dynamics 240:1100–1107, 2011. © 2011 Wiley-Liss, Inc.

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