Ancestral network module regulating prdm1 expression in the lamprey neural plate border

Authors

  • Natalya Nikitina,

    Corresponding author
    1. Division of Biology, California Institute of Technology, Pasadena, California
    2. School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, South Africa
    • School of Molecular and Cell Biology, University of the Witwatersrand, Private Bag 3, WITS 2050, Johannesburg, South Africa
    Search for more papers by this author
  • Leslie Tong,

    1. Division of Biology, California Institute of Technology, Pasadena, California
    Search for more papers by this author
  • Marianne E. Bronner

    Corresponding author
    1. Division of Biology, California Institute of Technology, Pasadena, California
    • School of Molecular and Cell Biology, University of the Witwatersrand, Private Bag 3, WITS 2050, Johannesburg, South Africa
    Search for more papers by this author

Abstract

prdm1 is an important transcriptional regulator that plays diverse roles during development of a wide variety of vertebrate and invertebrate species. prdm1 is required for neural crest specification in zebrafish, but not in mouse embryos. The role of this gene in neural crest formation in other species has not been examined, and its regulation during embryonic development is poorly understood. Here, we investigate the expression pattern, function, and the upstream regulatory inputs into prdm1 during lamprey neural crest development. prdm1 is strongly expressed in the lamprey neural plate border, suggesting a conserved ancestral role of this gene in the neural crest formation. We found that lamprey neural plate border expression of prdm1 is activated by Ap-2 and Msx, but is independent of Pax3/7 and Zic. Developmental Dynamics 240:2265–2271, 2011. © 2011 Wiley-Liss, Inc.

Ancillary