Special Issue Reviews–A Peer Reviewed Forum
Hippo signaling in Drosophila: Recent advances and insights
Article first published online: 25 AUG 2011
Copyright © 2011 Wiley Periodicals, Inc.
Special Issue: Special Issue on Drosophila
Volume 241, Issue 1, pages 3–15, January 2012
How to Cite
Staley, B. K. and Irvine, K. D. (2012), Hippo signaling in Drosophila: Recent advances and insights. Dev. Dyn., 241: 3–15. doi: 10.1002/dvdy.22723
- Issue published online: 15 DEC 2011
- Article first published online: 25 AUG 2011
- Manuscript Accepted: 5 AUG 2011
- NIH. Grant Number: 2R01 GM078620
- HFSP. Grant Number: RGP0016/2010
- imaginal disc
The Hippo signaling pathway emerged from studies of Drosophila tumor suppressor genes, and is now appreciated as a major growth control pathway in vertebrates as well as arthropods. As a recently discovered pathway, key components of the pathway are continually being identified, and new insights into how the pathway is regulated and deployed are arising at a rapid pace. Over the past year and a half, significant advances have been made in our understanding of upstream regulatory inputs into Hippo signaling, key negative regulators of Hippo pathway activity have been identified, and important roles for the pathway in regeneration have been described. This review describes these and other advances, focusing on recent progress in our understanding of Hippo signaling that has come from continued studies in Drosophila. Developmental Dynamics 241:3–15, 2012. © 2011 Wiley Periodicals, Inc.