Special Issue Reviews–A Peer Reviewed Forum
Generating neuronal diversity in the Drosophila central nervous system
Article first published online: 19 SEP 2011
Copyright © 2011 Wiley Periodicals, Inc.
Special Issue: Special Issue on Drosophila
Volume 241, Issue 1, pages 57–68, January 2012
How to Cite
Lin, S. and Lee, T. (2012), Generating neuronal diversity in the Drosophila central nervous system. Dev. Dyn., 241: 57–68. doi: 10.1002/dvdy.22739
- Issue published online: 15 DEC 2011
- Article first published online: 19 SEP 2011
- Manuscript Accepted: 24 AUG 2011
- central nervous system;
- neuronal diversity
Generating diverse neurons in the central nervous system involves three major steps. First, heterogeneous neural progenitors are specified by positional cues at early embryonic stages. Second, neural progenitors sequentially produce neurons or intermediate precursors that acquire different temporal identities based on their birth-order. Third, sister neurons produced during asymmetrical terminal mitoses are given distinct fates. Determining the molecular mechanisms underlying each of these three steps of cellular diversification will unravel brain development and evolution. Drosophila has a relatively simple and tractable CNS, and previous studies on Drosophila CNS development have greatly advanced our understanding of neuron fate specification. Here we review those studies and discuss how the lessons we have learned from fly teach us the process of neuronal diversification in general. Developmental Dynamics 241:57–68, 2012. © 2011 Wiley Periodicals, Inc.