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Tissue interaction is required for glenoid fossa development during temporomandibular joint formation

  1. Ying Wang1,2,‡,
  2. Chao Liu2,‡,
  3. Joseph Rohr2,
  4. Hongbing Liu2,
  5. Fenglei He2,†,
  6. Jian Yu2,
  7. Cheng Sun2,
  8. Lu Li2,
  9. Shuping Gu2,
  10. YiPing Chen2,*

Article first published online: 26 SEP 2011

DOI: 10.1002/dvdy.22748

Issue

Developmental Dynamics

Developmental Dynamics

Volume 240, Issue 11, pages 2466–2473, November 2011

Additional Information

How to Cite

Wang, Y., Liu, C., Rohr, J., Liu, H., He, F., Yu, J., Sun, C., Li, L., Gu, S. and Chen, Y. (2011), Tissue interaction is required for glenoid fossa development during temporomandibular joint formation. Dev. Dyn., 240: 2466–2473. doi: 10.1002/dvdy.22748

Author Information

  1. 1

    Department of Operative Dentistry and Endodontics, College of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P. R. China

  2. 2

    Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana

  1. †

    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York City, New York 10029

  1. ‡

    Drs. Wang and Liu contributed equally to this work.

*Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118

  1. ‡

    Drs. Wang and Liu contributed equally to this work.

Publication History

  1. Issue published online: 19 OCT 2011
  2. Article first published online: 26 SEP 2011
  3. Manuscript Accepted: 2 SEP 2011

Funded by

  • NIH. Grant Number: DE17792

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Keywords:

  • TMJ formation;
  • glenoid fossa development;
  • condyle;
  • tissue interaction;
  • Sox9

Abstract

The mammalian temporomandibular joint (TMJ) develops from two distinct mesenchymal condensations that grow toward each other and ossify through different mechanisms, with the glenoid fossa undergoing intramembranous ossification while the condyle being endochondral in origin. In this study, we used various genetically modified mouse models to investigate tissue interaction between the condyle and glenoid fossa during TMJ formation in mice. We report that either absence or dislocation of the condyle results in an arrested glenoid fossa development. In both cases, glenoid fossa development was initiated, but failed to sustain, and became regressed subsequently. However, condyle development appears to be independent upon the presence of the forming glenoid fossa. In addition, we show that substitution of condyle by Meckel's cartilage is able to sustain glenoid fossa development. These observations suggest that proper signals from the developing condyle or Meckel's cartilage are required to sustain the glenoid fossa development. Developmental Dynamics 240:2466–2473, 2011. © 2011 Wiley-Liss, Inc.

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