Hepatocyte growth factor–regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of smads and TAK1 in early mouse embryo
Article first published online: 26 SEP 2011
Copyright © 2011 Wiley-Liss, Inc.
Volume 240, Issue 11, pages 2474–2481, November 2011
How to Cite
Miura, S. and Mishina, Y. (2011), Hepatocyte growth factor–regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of smads and TAK1 in early mouse embryo. Dev. Dyn., 240: 2474–2481. doi: 10.1002/dvdy.22750
- Issue published online: 19 OCT 2011
- Article first published online: 26 SEP 2011
- Manuscript Accepted: 4 SEP 2011
- Intramural Research Program of the National Institute of Environmental Health Sciences. Grant Number: ES071003-11
- signal transduction;
Hepatocyte growth factor–regulated tyrosine kinase substrate that is encoded by Hgs promotes degradation of ubiquitinated signaling molecule in the early endosome. We previously reported that a targeted mutation in Hgs results in embryonic lethality soon after gastrulation in the mouse. Here, we report that downstream target genes for BMP signaling were highly down-regulated in the Hgs mutant embryos. We also showed that Hgs is required for phosphorylation of SMAD1/5/8 and TAK1/p38 to transduce BMP signaling. Furthermore, we found that HGS functions to localize TAK1 in early endosome for its activation. These results suggest that HGS is critical to localize TAK1 to early endosome for transducing BMP signaling for proper development. Our data revealed a new mechanism to modify BMP signaling by Hgs during early mouse development. Developmental Dynamics 240:2474–2481, 2011. © 2011 Wiley-Liss, Inc.