Special Issue Reviews–A Peer Reviewed Forum
The origin of intestinal stem cells in Drosophila
Article first published online: 3 OCT 2011
Copyright © 2011 Wiley Periodicals, Inc.
Special Issue: Special Issue on Drosophila
Volume 241, Issue 1, pages 85–91, January 2012
How to Cite
Micchelli, C. A. (2012), The origin of intestinal stem cells in Drosophila. Dev. Dyn., 241: 85–91. doi: 10.1002/dvdy.22759
- Issue published online: 15 DEC 2011
- Article first published online: 3 OCT 2011
- Manuscript Accepted: 8 SEP 2011
- Drosophila; intestinal stem cells; AMPs
Renewing tissues in the adult organism such as the gastrointestinal (GI) epithelium depend on stem cells for epithelial maintenance and repair. Yet, little is known about the developmental origins of adult stem cells and their niches. Studies of Drosophila adult midgut precursors (AMPs), a population of endodermal progenitors, demonstrate that adult intestinal stem cells (ISCs) arise from the AMP lineage and provide insight into the stepwise process by which the adult midgut epithelium is established during development. Here, I review the current literature on AMPs, where local, inductive and long-range humoral signals have been found to control progenitor cell behavior. Future studies will be necessary to determine the precise mechanism by which adult intestinal stem cells are established in the endodermal lineage. Developmental Dynamics 241:85–91, 2012. © 2011 Wiley Periodicals, Inc.