Special Issue Reviews–A Peer Reviewed Forum
Glycosphingolipids in signaling and development: From liposomes to model organisms
Article first published online: 28 OCT 2011
Copyright © 2011 Wiley Periodicals, Inc.
Special Issue: Special Issue on Drosophila
Volume 241, Issue 1, pages 92–106, January 2012
How to Cite
Pontier, S. M. and Schweisguth, F. (2012), Glycosphingolipids in signaling and development: From liposomes to model organisms. Dev. Dyn., 241: 92–106. doi: 10.1002/dvdy.22766
- Issue published online: 15 DEC 2011
- Article first published online: 28 OCT 2011
- Manuscript Accepted: 22 SEP 2011
- European Molecular Biology Organization. Grant Number: EMB0-ALTF553-2009
- European Commission. Grant Number: IRG-277152
Since the launch of the raft hypothesis in 1997, data generated in liposomes and cultured cells have highlighted the role of glycosphingolipids (GSLs) in the dynamic organization of biological membranes and the activity of signaling complexes. In parallel studies, genetic analysis of the GSL synthetic pathway has begun to reveal some of the specific roles of GSLs in vivo. Here, we review the role of GSLs in signaling in the context of a refined raft hypothesis. Recent genetic studies in worms, flies, and mice give us the opportunity to integrate these in vivo data with earlier in vitro liposome studies. Developmental Dynamics 241:92–106, 2012. © 2011 Wiley Periodicals, Inc.