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Keywords:

  • branching morphogenesis;
  • ROCK;
  • MLC2;
  • fibronectin;
  • focal adhesions;
  • integrin activation

Abstract

E13 mouse submandibular salivary gland (SMG) cultured for 24 hours ex vivo and immunostained for collagen IV (blue) to mark the basement membrane, Na+/K+ ATPase (green) which is preferential for the epithelium, and the focal adhesion protein vinculin (red) to delineate cell-matrix adhesions. Note that vinculin localizes the most strongly to regions of cell-matrix contact immediately adjacent to the basement membrane. From Daley et al., Developmental Dynamics 240:2069–2083, 2011.