Special Issue Reviews–A Peer Reviewed Forum
Drosophila as a model for epithelial tube formation
Article first published online: 14 NOV 2011
Copyright © 2011 Wiley Periodicals, Inc.
Special Issue: Special Issue on Drosophila
Volume 241, Issue 1, pages 119–135, January 2012
How to Cite
Maruyama, R. and Andrew, D. J. (2012), Drosophila as a model for epithelial tube formation. Dev. Dyn., 241: 119–135. doi: 10.1002/dvdy.22775
- Issue published online: 15 DEC 2011
- Article first published online: 14 NOV 2011
- Accepted manuscript online: 20 OCT 2011 02:27PM EST
- Manuscript Accepted: 10 OCT 2011
- epithelial migration;
- Malpighian tubules;
- salivary gland;
Epithelial tubular organs are essential for life in higher organisms and include the pancreas and other secretory organs that function as biological factories for the synthesis and delivery of secreted enzymes, hormones, and nutrients essential for tissue homeostasis and viability. The lungs, which are necessary for gas exchange, vocalization, and maintaining blood pH, are organized as highly branched tubular epithelia. Tubular organs include arteries, veins, and lymphatics, high-speed passageways for delivery and uptake of nutrients, liquids, gases, and immune cells. The kidneys and components of the reproductive system are also epithelial tubes. Both the heart and central nervous system of many vertebrates begin as epithelial tubes. Thus, it is not surprising that defects in tube formation and maintenance underlie many human diseases. Accordingly, a thorough understanding how tubes form and are maintained is essential to developing better diagnostics and therapeutics. Among the best-characterized tubular organs are the Drosophila salivary gland and trachea, organs whose relative simplicity have allowed for in depth analysis of gene function, yielding key mechanistic insight into tube initiation, remodeling and maintenance. Here, we review our current understanding of salivary gland and trachea formation – highlighting recent discoveries into how these organs attain their final form and function. Developmental Dynamics 241:119–135, 2012. © 2011 Wiley Periodicals, Inc.