Special Issue Disease Connections
OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye
Version of Record online: 23 NOV 2011
Copyright © 2011 Wiley Periodicals, Inc.
Special Issue: Special Issue on Drosophila
Volume 241, Issue 1, pages 215–228, January 2012
How to Cite
Terrell, D., Xie, B., Workman, M., Mahato, S., Zelhof, A., Gebelein, B. and Cook, T. (2012), OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye. Dev. Dyn., 241: 215–228. doi: 10.1002/dvdy.22782
- Issue online: 15 DEC 2011
- Version of Record online: 23 NOV 2011
- Accepted manuscript online: 7 NOV 2011 01:24PM EST
- Manuscript Accepted: 19 OCT 2011
- NIH. Grant Number: R01-EY017907
Additional Supporting Information may be found in the online version of this article.
|DVDY_22782_sm_SuppFig1.tif||8731K||Supplementary Figure 1. A: Quantification of OTX expression shown in the western blot in Figure 1C. B: Western blot analysis of OTX factors expressed in S2 cell lines, indicating that they are expressed at similar levels. C: Western blot analysis of FLAG-tagged mutant CRX proteins from adult Drosophila head lysates. All mutant CRX proteins are expressed, albeit at different levels. Similarly to what was previously reported in vertebrate cell culture lines (Nichols et al., 2010), the CRX 138fs48 mutation increases the steady state levels of the protein. The R90W mutant has slightly reduced levels compared to wild-type CRX. Actin serves as a loading control.|
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