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Research Article
Differential contribution of Neurog1 and Neurog2 on the formation of cranial ganglia along the anterior-posterior axis
Article first published online: 18 NOV 2011
DOI: 10.1002/dvdy.22785
Copyright © 2011 Wiley-Liss, Inc.
Additional Information
How to Cite
Takano-Maruyama, M., Chen, Y. and Gaufo, G. O. (2012), Differential contribution of Neurog1 and Neurog2 on the formation of cranial ganglia along the anterior-posterior axis. Developmental Dynamics, 241: 229–241. doi: 10.1002/dvdy.22785
Publication History
- Issue published online: 24 JAN 2012
- Article first published online: 18 NOV 2011
- Accepted manuscript online: 4 NOV 2011 08:34AM EST
- Manuscript Accepted: 28 OCT 2011
Funded by
- NIH. Grant Number: NS060658
- Whitehall Foundation
Keywords:
- neural crest;
- epibranchial placode;
- parasympathetic ganglion;
- visceral sensory ganglion;
- autonomic nervous system
Key findings:
Specification of epibranchial placode-derived nodose ganglion requires both Neurog1 and Neurog2.
Specification of neural crest-derived parasympathetic otic ganglion requires both Neurog1 and Neurog2.
Loss of Neurog genes associated with the complementary loss of visceral sensory (nodose) and parasympathetic (otic) ganglia due to apoptosis.
Neurog1 and Neurog2 are transiently expressed in the neural crest fated for the parasympathetic otic ganglion lineage.
Abstract
Background: The neural crest (NC) and placode are transient neurogenic cell populations that give rise to cranial ganglia of the vertebrate head. The formation of the anterior NC- and placode-derived ganglia has been shown to depend on the single activity of either Neurog1 or Neurog2. The requirement of the more posterior cranial ganglia on Neurog1 and Neurog2 is unknown. Results: Here we show that the formation of the NC-derived parasympathetic otic ganglia and placode-derived visceral sensory petrosal and nodose ganglia are dependent on the redundant activities of Neurog1 and Neurog2. Tamoxifen-inducible Cre lineage labeling of Neurog1 and Neurog2 show a dynamic spatiotemporal expression profile in both NC and epibranchial placode that correlates with the phenotypes of the Neurog-mutant embryos. Conclusion: Our data, together with previous studies, suggest that the formation of cranial ganglia along the anterior-posterior axis is dependent on the dynamic spatiotemporal activities of Neurog1 and/or Neurog2 in both NC and epibranchial placode. Developmental Dynamics 241:229–241, 2012. © 2011 Wiley Periodicals, Inc.