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Research Article
Myocardial progenitors in the pharyngeal regions migrate to distinct conotruncal regions
Article first published online: 19 DEC 2011
DOI: 10.1002/dvdy.23714
Copyright © 2011 Wiley Periodicals, Inc.
Additional Information
How to Cite
Takahashi, M., Terasako, Y., Yanagawa, N., Kai, M., Yamagishi, T. and Nakajima, Y. (2012), Myocardial progenitors in the pharyngeal regions migrate to distinct conotruncal regions. Developmental Dynamics, 241: 284–293. doi: 10.1002/dvdy.23714
Publication History
- Issue published online: 24 JAN 2012
- Article first published online: 19 DEC 2011
- Accepted manuscript online: 6 DEC 2011 02:26PM EST
- Manuscript Accepted: 22 NOV 2011
Funded by
- JSPS Grants-in-Aid for Scientific Research. Grant Numbers: 20390052, 21659047
Keywords:
- secondary heart field;
- anterior heart field;
- migration;
- conotruncus;
- heart development
Key findings:
Myocardial progenitors from the secondary heart field (SHF) and anterior heart field (AHF) contribute to distinct conotruncal regions.
Progenitor cells from the right and left SHF migrate rotationally to form left dorsal wall of the OFT and right ventral wall of the OFT, respectively.
Progenitors from the AHF migrate non-rotationally and contribute to ventral wall of the OFT.
Abstract
Background: The cardiac progenitor cells for the outflow tract (OFT) reside in the visceral mesoderm and mesodermal core of the pharyngeal region, which are defined as the secondary and anterior heart fields (SHF and AHF), respectively. Results: Using chick embryos, we injected fluorescent-dye into the SHF or AHF at stage 14, and the destinations of the labeled cells were examined at stage 31. Labeled cells from the right SHF were found in the myocardium on the left dorsal side of the OFT, and cells from the left SHF were detected on the right ventral side of the OFT. Labeled cells from the right and left AHF migrated to regions of the ventral wall of the OFT close to the aortic and pulmonary valves, respectively. Conclusion: These observations indicate that myocardial progenitors from the SHF and AHF contribute to distinct conotruncal regions and that cells from the SHF migrate rotationally while cells from the AHF migrate in a non-rotational manner. Developmental Dynamics 241:284–293, 2012. © 2011 Wiley Periodicals, Inc.